December 10, 2017
Visiting speaker Dr Georgios S. Stamatakos will give a talk on “The In Silico Oncology and In Silico Medicine Group of ICCS-SECE-NTUA and the Large Scale EU-US Research Project CHIC on In Silico Oncology” on Monday 18/12.
Abstract
In silico medicine, an emergent scientific and technological domain based on clinically driven and clinically oriented multiscale biomodeling, appears to be the latest trend regarding the translation of mathematical and computational biological science to clinical practice through massive exploitation of information technology. In silico (i.e. on the computer) experimentation for each individual patient using their own multiscale biomedical data is expected to significantly improve the effectiveness of treatment in the future, since reliable computer predictions could suggest the optimal treatment scheme(s) and schedules(s) for each separate case. In this context, a brief outline of the structure and the activities of the In Silico Oncology and In Silico Medicine Group (ISO&ISM_G), Institute of Communication and Computer Systems (ICCS), School of Electrical and Computer Engineering (SECE), National Technical University of Athens (NTUA) will be presented. Additionally, the large scale EU-US integrating research project CHIC entitled: “CHIC – Computational Horizons in Cancer: Developing Meta- and Hyper-Multiscale Models and Repositories for In Silico Oncology” that was funded by the European Commission (EC) and coordinated by ISO&ISM_G-ICCS-NTUA will be outlined. Within the framework of CHIC, a number of highly innovative meta- and hyper-multiscale models and repositories for in silico oncology were developed, clinically adapted, and partly clinically validated. Complex technological systems supporting and facilitating the process of hypermodel building and execution aiming at treatment personalization were also developed and successfully tested. It is noted that the outcome of the CHIC project was both assessed as “excellent” and denoted as “great achievements” by EC.
Georgios S. Stamatakos (www.ece.ntua.gr/en/staff/400) is Research Professor of Analysis and Simulation of Biological Systems and their Interaction with Electromagnetic Radiation at the Institute of Communication and Computer Systems (ICCS), School of Electrical and Computer Engineering (SECE), National Technical University of Athens (NTUA). He is also a Visiting Professor at the School of Electrical and Computer Engineering, NTUA. He has founded and directs the In Silico Oncology and In Silico Medicine Group of ICCS-SECE-NTUA (www.in-silico-oncology.iccs.ntua.gr). He holds a Diploma/MSc degree in electrical engineering from NTUA, an MSc degree in bioengineering from the University of Strathclyde, Glasgow, UK, and a Ph.D. degree in physics (biophysics) from NTUA. He proposed the concept and the system of “Oncosimulator” as well as the term and the concept of “in silico oncology”. The latter denotes a new clinical trial driven scientific and technological discipline, primarily based on multiscale mechanistic biomodelling and in silico experimentation (i.e. experimentation on the computer). In silico oncology has also proved a precursor of the generic in silico medicine (https://en.wikipedia.org/wiki/In_silico_medicine). He pioneered the development of the Oncosimulator of the European Commission (EC) and Japan co-funded ACGT Integrated Project, a “world first” (http://cordis.europa.eu/result/rcn/86061_en.html). G. Stamatakos was the scientific and the overall coordinator as well as the leader of the fundamental science part of the large scale EU-US integrating research project CHIC on in silico oncology (http://www.chic-vph.eu/). The outcome of the latter was assessed by EC as excellent. His research interests include in silico oncology, in silico medicine, multiscale cancer modeling, computational medicine, systems medicine, precision medicine, the Virtual Physiological Human (VPH) initiative, systems biology, bioinformatics, biomedical engineering, bioengineering, bioelectromagnetics, biooptics, computational electromagnetics, software engineering and applied mathematics.